Fig. 2
From: Network biology discovers pathogen contact points in host protein-protein interactomes
Network analyses of nodes in various layers of AI-1MAIN. a Schematic illustration of network layering using the weighted k-shell decomposition method. Connected hypothetical network (left; gray nodes) and decomposed network into three shells (right; k = 1, k = 2, and k = 3 in green, red, and black colors) are shown. b Distribution of average degree of each shell from the innermost of the network (core) designated as 1 to the periphery of the network denoted as 1000 in AI-1MAIN. Effector targets and non-targets are shown in red and blue nodes, respectively (r2 = 0.67 and Mann–Whitney–Wilcoxon Test P < 2.2 × 10−16). c, d Average degree (Welch’s t-test P = 1.57 × 10−14) (c) and average betweenness (Welch’s t-test P = 4.27 × 10−12) (d) for internal layers AI-1MAIN proteins (red) and peripheral layers AI-1MAIN proteins (blue) are plotted. e Distribution of average information centrality (IC) for each shell starting from the core of the network in AI-1MAIN (r2 = 0.82 and Mann–Whitney–Wilcoxon test P < 2.2 × 10−16)
