Fig. 3
From: Network biology discovers pathogen contact points in host protein-protein interactomes
Functional properties of effector targets. a Distribution of effector targets (red) and non-targets (blue) within shells of AI-1MAIN encompassing varied sizes as well as locations with reference to the core indicated as 1. A shell index ranges from 1 to 1000 in logarithmic scale is demonstrated. b Percentage of effector targets (red) and non-targets (blue) in two categories of nodes, internal layers AI-1MAIN proteins and peripheral layers AI-1MAIN proteins, are displayed (hypergeometric P = 2.61 × 10−48). c, d Distribution of effector targets (red) and non-targets (blue) within shells of degree-preserving random network (c) and non-degree-preserving random network (d) are shown. e, f Phenotypic overrepresentation analyses among the nodes of effector targets (red) and non-targets (blue). Enrichment of CND (hypergeometric P = 0.05) and immune-related phenotypes (hypergeometric P = 2.55 × 10−6) in e and f, respectively for effector targets (red) are shown. Overrepresentation of no immune-related phenotypes in nodes located in peripheral layers are demonstrated (hypergeometric P = 0.035)
