Table 1 Baseline characteristics of derivation, validation, and testing cohort at initial diagnosis
Variable | Derivation cohort no. (%) | Internal testing cohort no. (%) | P value | Multicenter testing cohort no. (%) | P value |
|---|---|---|---|---|---|
Age (years) | 0.441 | <0.001 | |||
≤50 | 370 (37.8) | 249 (39.7) | 199 (48.1) | ||
>50 | 609 (62.2) | 378 (60.3) | 215 (51.9) | ||
Gender | 0.113 | 0.043 | |||
Male | 889 (90.8) | 554 (88.4) | 361 (87.2) | ||
Female | 90 (9.2) | 73 (11.6) | 53 (12.8) | ||
HBV infection | 0.086 | 0.813 | |||
No | 33 (3.4) | 32 (5.1) | 15 (3.6) | ||
Yes | 946 (96.6) | 595 (94.9) | 399 (96.4) | ||
AFP (IU/ml) | 0.493 | 0.314 | |||
<25 | 318 (32.5) | 214 (34.1) | 146 (35.3) | ||
≥25 | 661 (67.5) | 413 (65.9) | 268 (64.7) | ||
Child-Pugh class | 0.815 | 0.602 | |||
A | 841 (85.9) | 536 (85.5) | 360 (87.0) | ||
B | 138 (14.1) | 91 (14.5) | 54 (13.0) | ||
Tumor size (cm) | 0.727 | 0.939 | |||
Mean ± SD | 7.20 ± 3.57 | 7.07 ± 3.48 | 7.12 ± 3.51 | ||
≤5 | 329 (33.6) | 216 (34.4) | 140 (33.8) | ||
>5 | 650 (66.4) | 411 (65.6) | 274 (66.2) | ||
Number of lesions | 0.428 | 0.956 | |||
≤3 | 391 (39.9) | 238 (38.0) | 166 (40.1) | ||
>3 | 588 (60.1) | 389 (62.0) | 248 (59.9) |
