Fig. 1
From: Gut vagal sensory signaling regulates hippocampus function through multi-order pathways
Schematic illustration of subdiaphragmatic vagus nerve ablative disconnection methods. a Classic total subdiaphragmatic vagotomy (SDV) surgical method consists of lesioning the dorsal and ventral subdiaphragmatic vagus nerve, eliminating 100% of vagal afferent (sensory) and efferent (motor) signaling below the diaphragm. b The novel CCK saporin (CCK-SAP) approach consists of nodose ganglia injections of saporin conjugated to cholecystokinin to specifically ablate ~ 80% of vagal gastrointestinal (GI)-innervating afferent signaling, while leaving 100% of vagal efferent and supradiaphragmatic vagal afferent signaling intact (see ref. 17). (DMX dorsal motor nucleus of the vagus nerve, mNTS medial nucleus tractus solitarius). [Cartoon schematic made by authors based on ref. 42]
