Fig. 4
From: Gut vagal sensory signaling regulates hippocampus function through multi-order pathways
Peripheral administration of CCK activates c-Fos protein expression in the dorsal CA3 (dCA3) and dentate gyrus (DG). Intraperitoneal injections of CCK (n = 6) (a vagally mediated gastrointestinal-derived satiation signal) increases the number of c-Fos-immunoreactive (-ir) cells (a marker for neural activation) expressed in the a dCA3 and b DG vs. saline (n = 5) treatment (ANOVA, F[1,9] = 20.236, p = 0.001492 (dCA3), F[1,9] = 37.917, p = 0.000167 (DG)). Representative images of immunohistochemical staining of c-Fos-ir protein (green) in the c dCA3 and d DG. Scale bar: 25 μm. (*P < 0.05 vs. i.p. saline controls; data are mean ± SEM.; CCK cholesystokinin, i.p. intraperional, DG dentate gyrus, dCA3 dorsal CA3, CA3sr CA3 stratum radiatum, CA3sp CA3 pyramidal layer, DGmo dentate gyrus molecular layer, DGpo DG polymorph layer, DGsg DG granule cell layer)
