Fig. 1
From: Evidence that neutrophils do not promote Echis carinatus venom-induced tissue destruction
ECV-induced tail injury and mortality in neutrophil-deficient mice and mice treated with cyclophosphamide or DNAse I. a–h Tail injury scores (a–d) and survival (percentage of live animals) after injection of E. carinatus sochukeri venom (3 mg/kg) (e–h) in mice treated with cyclophosphamide or vehicle (PBS) (n = 12/group) (a, e), neutrophil-depleting anti-Ly6G antibodies or isotype control antibodies (n = 12/group) (b, f), and in neutrophil-depleted diphtheria toxin (DT)-treated PMNDTR mice (n = 15) or DT-treated PMNWT littermate controls (n = 9) (c, g), and in neutrophil-deficient Gfi1KI/KI mice or neutrophil-sufficient Gfi1KI/+ littermates injected with E. carinatus sochukeri venom (3 mg/kg) alone or together with 500 U DNAse I (n = 8–9/group) (d, h). Data are pooled from two or three independent experiments. White numbers in a–d indicate number of live animals per group at each time point. *P < 0.05 and ***P < 0.01 by two-tailed Mann–Whitney U test (a, d) or Mantel–Cox log-rank test (e–h)
