Fig. 8 | Nature Communications

Fig. 8

From: Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages

Fig. 8

Difference in nano-protein interaction between SNH and CNT. a Gel electropherogram of cellular proteins that bound with different nanocarbons after cell lysate incubations. The resultant stripes revealed the high affinities of part intracellular proteins with nanocarbons. b Gel electropherogram of different nanocarbon dispersions that contained 0.5% bovine serum albumin (BSA). c Venn diagrams of identified proteins among different nanocarbon groups. SNH shared near half of proteins with MNT and SNT separately. d Hierarchical clustering analysis of affinitive proteins among five nanocarbon groups, revealing the distinctions of SNH with CNT in protein class. e Overrepresentation (OR) tests of affinitive proteins in different nanocarbon groups based on gene ontology (GO) analysis. f Intracellular distribution of shared affinitive proteins for five nanocarbon groups. g Protein-binding abundance comparisons among different nanocarbon groups via heat mapping analysis. The values in heat map indicated the logarithmic intensities of proteins based on label-free quantification (LFQ) detected by LC-MS/MS

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