Fig. 5
From: Helicase promotes replication re-initiation from an RNA transcript
Proposed T7 replication re-initiation model. Cartoons illustrate a proposed model for T7 replication re-initiation. The replisome here consists of leading-strand DNAP and helicase. When the replisome encounters a leading-strand lesion, helicase may continue to unwind processively via association with a non-replicating DNAP. The two proteins form a complex clamping crossed the fork junction, poising the DNAP for replication re-initiation. After collision with a TEC, the helicase-DNAP displaces the RNAP and the DNAP then uses the RNA as a primer to re-initiate the replication
