Fig. 8
Vestigial esterase subdomain-binding antibodies mediate neutralization by diverse mechanisms. a Comparison of H3v-47 (magenta) with structurally characterized esterase subdomain-binding antibodies, including H5M9 binding to H5 HA (PDB code 4MHH, blue) and CR8071 (PDB code 4FQJ, orange) binding to influenza B HA. The HAs from all these complexes are aligned, and only the three protomers of A/Minnesota/11/2010 H3N2v HA trimer are shown as surface in light, middle or dark gray, respectively. The HAs from all these HA-antibody complexes are aligned. The vestigial esterase subdomain is highlighted in red. These antibodies target the HA vestigial esterase subdomain using different angles of approach. b-c The epitopes of CR8071 (b) and H5M9 (c) are mapped onto the surfaces of the corresponding HAs
