Fig. 5
From: Immuno-detection by sequencing enables large-scale high-dimensional phenotyping in cells
Enriched kinase inhibitor probe sets show differentially affected molecular phenotypes. a K-means clustering of mean probe effect on molecular phenotypes per kinase probe set. b Principal component analysis on mean probe effects shows in PC1 and PC4 distinct kinase probe-set clusters. Colours based on K-means clustering of the data (see a). c The mean and standard error of probe effect on molecular phenotypes, per probe set inhibiting kinases EGFR, DYRK1A, NUAK1, RSK1/2/3/4 and p70-Ribosomal S6 kinase. Compared to EGFR the other four kinases have a comparable phenotypic profile with several changes different effects on molecular phenotypes (black nodes, p < 0.05, t-test)
