Table 1 Description of PR loci previously identified by GWAS among those of European descent
European ancestry index SNPs in previously GWAS identified PR loci | Non-red SNPs | AA PR | Missense | DHS | Cardiac eQTL | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Locus | SNP | Chr | Closest gene | CA | CAF | Beta (ms) | SE (ms) | P-value | n | P < 0.05 | r2 > 0.8 | r2 > 0.8 | FDR < 0.05 |
1 | rs4430933 | 2 | MEIS1 | A | 0.39 | 1.3 | 0.11 | 5.06E−30 | 1 | YES | – | YES | MEIS1 |
2 | rs6599250 | 3 | SCN10A | T | 0.41 | 3.8 | 0.11 | 4.42E−242 | 2 | YES | SCN10A | YES | SCN10A & SCN5A |
3 | rs11708996 | 3 | SCN5A | C | 0.15 | 3.1 | 0.18 | 1.06E−68 | 5 | YES | SCN5A | YES | – |
4 | rs343849 | 4 | ARHGAP24 | A | 0.3 | −2.1 | 0.13 | 3.12E−61 | 1 | YES | – | YES | – |
5 | rs255292 | 5 | BNIP1/NKX2-5 | C | 0.42 | −1.1 | 0.12 | 5.99E−21 | 1 | YES | – | YES | BNIP1 |
6 | rs3807989 | 7 | CAV1/CAV2 | A | 0.41 | 2 | 0.12 | 8.65E−69 | 1 | YES | – | YES | CAV1 |
7 | rs652673 | 11 | WNT11 | C | 0.22 | −0.8 | 0.15 | 4.41E−08 | 1 | – | – | – | – |
8 | rs17287293 | 12 | C12orf67/SOX5 | G | 0.15 | −2.2 | 0.16 | 2.33E−41 | 1 | YES | – | – | – |
9 | rs1896312 | 12 | TBX3 | C | 0.29 | 1.6 | 0.13 | 1.16E−34 | 4 | – | – | – | – |
10 | rs6489953 | 12 | TBX5 | C | 0.17 | 1.2 | 0.15 | 1.94E−16 | 2 | – | – | – | – |
