Fig. 8
From: Cell entry of a host-targeting protein of oomycetes requires gp96
Model for the self-translocation of SpHtp3 into host cells and its vesicle release. The fish-pathogenic oomycete S. parasitica secretes several effector proteins during different stages of infection. The nuclease SpHtp3 is secreted in the later stages of infection. S. parasitica acidifies the pH of its environment, which likely leads to the exposure of a gp96-like protein to the host cell surface. The gp96-like protein is working as a receptor and mediates the translocation of SpHtp3 via lipid rafts into the cell. Finally, SpHtp3 is released from vesicles with the help of other effector proteins, as SpHtp1, into the cytosol where it is functionally active as a nuclease
