Fig. 1

Schematic representations. a–d Synthesis of DOX-loaded PEG-CCM@APTES-COF-1 with cellular uptake at weak acidic tumor tissue/cells (i.v. injection intravenous injection). e Synthesis of PEG-CCM amphiphilic block copolymers containing hydrophobic blocks based on the unplugging of the PEG-CCM polymer from the APTES-COF-1 pores