Fig. 5

In vivo evaluation of antitumor efficacy. a Mean tumor volumes and b mean tumor weights after excision at day 28 (n = 5). c Representative photographs of mice tumors after treatment and d body weights of the mice in different groups after treatment at different time intervals. Relative antitumor assay after intravenous injection into the HeLa tumor-bearing mice with saline, free DOX, PEG₃₅₀-CCM@APTES-COF-1, PEG₁₀₀₀-CCM@APTES-COF-1, PEG₂₀₀₀-CCM@APTES-COF-1, PEG₃₅₀-CCM@APTES-COF-1@DOX, PEG₁₀₀₀-CCM@APTES-COF-1@DOX, and PEG₂₀₀₀-CCM@APTES-COF-1@DOX at an equivalent dose of 1.5 mg DOX kg⁻¹ in PBS every 3 days. Data were presented as the mean ± SD (n = 5). Each data point represents the average and SD (one above and one below for the error bars), as measured from five different analysis in a single experiment