Table 1 Mendelian randomisation results
From: Elucidating the genetic basis of social interaction and isolation
Exposure | Outcome | No. SNPs used | Model | Beta | SE | P value | Het. P-val |
|---|---|---|---|---|---|---|---|
IVW | 0.017 | 0.004 | 2.30 × 10−6 | 1 | |||
BMI (GIANT) | Loneliness (UKBB) | 96 | Egger’s | 0.015 | 0.014 | 0.256 | |
WM | 0.021 | 0.007 | 1.43 × 10−3 | ||||
IVW | 0.037 | 0.015 | 1.65 × 10−2 | 1 | |||
BMI (GIANT) | DS (23andMe) | 96 | Egger’s | 0.042 | 0.046 | 0.365 | |
WM | 0.060 | 0.026 | 2.27 × 10−2 | ||||
Loneliness (UKBB) | BMI (UKBB) | 13 | IVW | 3.571 | 0.532 | 1.86 × 10−11 | 2.14 × 10−39 |
Egger’s | 14.843 | 7.601 | 0.051 | ||||
WM | 3.553 | 0.986 | 3.15 × 10−4 | ||||
IVW | 0.281 | 0.040 | 1.20 × 10−12 | 3.30 × 10−14 | |||
DS (23andMe) | BMI (UKBB) | 63 | Egger’s | 0.399 | 0.649 | 0.539 | |
WM | 0.294 | 0.089 | 9.15 × 10−4 | ||||
IVW | -0.043 | 0.079 | 0.585 | 0.016 | |||
Lonely (UKBB) | BMI (GIANT) | 15 | Egger’s | 1.689 | 0.913 | 0.064 | |
WM | 0.208 | 0.103 | 0.108 |
