Fig. 1 | Nature Communications

Fig. 1

From: Human in vivo-generated monocyte-derived dendritic cells and macrophages cross-present antigens through a vacuolar pathway

Fig. 1

Ascites DCs are distinct from classical DCs. Purified ascites DCs, ascites macrophages, tonsil DCs, and blood monocytes were analyzed by single-cell RNA-seq using a Drop-seq approach. Combined single-cell transcriptomes were analyzed. a, b t-SNE representation of cell clusters identified using unsupervised clustering. Each dot represents an individual cell. a Colors represent sample origin; don donor. b Colors represent identified clusters. Clusters are manually ordered and cell numbers for each cluster is indicated. c Heatmap of scaled expression (log values of UMI) for the top 20 differentially expressed genes of each cluster (based on log fold change)

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