Fig. 4
From: Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases
S1P3 is expressed in the neuroinflammatory response of patients’ brain metastasis specimens. Fresh frozen sections of nine resected brain metastases of breast and lung cancers, nine of which were previously described19, were stained for S1P3 (green) and GFAP (red). Nuclei are DAPI stained (blue). a Specimen #4, ER-, PR-, HER2+ breast cancer. b Specimen #5, ER-, PR-, HER2+ breast cancer. Co-staining of S1P3 and activated astrocytes in the tumor microenvironment is seen. A summary of all staining is presented in Supplementary Data 3. (Scale bar = 50 µm)
