Fig. 7
From: Abnormal RNA stability in amyotrophic lateral sclerosis
Correlating RNA stability and protein abundance in ALS iPSCs. Linear regression of RNA stability (as measured by the RNA stability index for each transcript, or the abundance at 6 h/0.5 h) and protein abundance determined by MS. A significant (p < 0.0001) association was detected between RNA stability and protein abundance in control, C9ALS and sALS iPSCs for all transcripts (top row, a−c) and for those involved in oxidative phosphorylation (Ox/phos, bottom row, g−i). However, no such relationship was identified for ribosomal protein-encoding transcripts and their corresponding proteins (middle row, d−f). Representative scatter plots are shown from one line each of control, C9ALS and sALS iPSCs; identical results were obtained upon examination of other lines. p value determined by extra sum-of-squares F test
