Fig. 3

IMD alleviated the vessel leakage in lung, kidney, and liver. C57/BL6 female (8–10 weeks, 20–25 g, housed in SPF conditions, n = 7) WT or IMD^−/− mice were injected IMD₄₀ (0.5 mg/kg) or IMD_inh (1 mg/kg) subcutaneously 1 h before LPS administration (24 mg/kg) or CLP surgery. The EB leakage of lung, kidney, and liver from LPS-treated mice (a–c) or CLP-treated mice (d–f) was determined by optical density (OD 630 nm). Data was presented as scatter plots with mean ± SD (n = 7 per group). Significance was assessed by Kruskal–Wallis test followed by non-parametric Dunn’s post-hoc analysis. The control mice (WT or IMD^−/−) was compared by Mann–Whitney test separately