Fig. 7
IMD significantly improved the survival of septic mice. a–e Kaplan–Meier survival analysis of the septic mice. a, b The mice were treated with saline, IMD40 (0.5 mg/kg) or IMDinh (1 mg/kg) 1 h before CLP surgery (short-term procedure, n = 10; or long-term procedure, n = 16) and every day for 3 days. c, d The mice (n = 20) received long-term CLP procedure treated with IMD40 at different dose (c) or timing (d). e The extended long-term CLP model using WT, IMD−/− mice, and IMD−/− mice (n = 12) rescued by IMD40 (subcutaneous injection, 0.25 mg/kg/day, 1 h before surgery and every day for 3 days). Each group was compared with the CLP-alone group, and significance was assessed by log rank test
