Fig. 3
From: TCM visualizes trajectories and cell populations from single cell data
TCM preserves the global developmental trajectories for the visualization of temporal single cell expression data. a-c TCM shows superior performance pertaining to the discovery of two major lineages of anterior and mid primitive streak (PS), and separating individual subpopulations compared to (c) t-SNE and (d) diffusion map on the visualization of a scRNA-seq dataset of hESC derived mesodermal lineages. d–f TCM shows superior performance compared to (e) t-SNE and (f) diffusion map on the reconstruction of the bifurcation of somatic and primordial germ cells (PGCs), and the female (17 weeks after gestation) and male (19 weeks after gestation) PGCs on a temporal scRNA-seq dataset of human somatic cell and PGC development from weeks 4 to 19 after gestation
