Fig. 2 | Nature Communications

Fig. 2

From: Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory

Fig. 2

Spatial and temporal information is transmitted along separate HPC-AON circuit elements. a Diagram depicting location of ArchT infusions within the HPC and optic fibre implantations above the AON in both experimental groups. iHPC terminals are predominantly found in the lAON (left) whereas vHPC fibres preferentially innervate the mAON (right). b Inhibition of both iHPC-lAON and vHPC-mAON pathways impaired spatial odour memory (GFP: n = 10; iHPC-lAON: n = 12; vHPC-mAON: n = 12; one-way ANOVA, F(2,31) = 11.65, ***P < 0.0005). c Inhibition of the vHPC-mAON, but not iHPC-lAON pathway impaired memory for the temporal order of a sequence of odours (GFP: n = 12; iHPC-lAON: n = 12; vHPC-mAON: n = 16; one-way ANOVA, F(2,37) = 9.235, ***P < 0.005). d HPC-AON pathway is not necessary for context-independent novel odour recognition (all groups: n = 10; one-way ANOVA, F(2,27) = 1.824, NS, P = 0.1807). Scale bars represent 1 mm. Coordinates indicate anteroposterior position from bregma. Data are presented as mean ± SEM

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