Fig. 3 | Nature Communications

Fig. 3

From: Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory

Fig. 3

HPC-AON pathways contribute distinct spatiotemporal information during episodic odour recall. a Top: illustration of the episodic memory test paradigm. Bottom: heat maps depicting group average position (left) and pie charts representing the percent investigation time (right) during the retrieval phase of the episodic memory test (all groups: n = 12). b Comparison of percent investigation time for all groups during the retrieval phase of the episodic memory test (two-way ANOVA, treatment-by-odour interaction F(6,132) = 9.532, ****P < 0.0001, main effect of odour F(3,132) = 5.415, **P < 0.005). c iHPC-lAON pathway inhibition impaired the spatial, but not temporal component of odour memory, while vHPC-mAON pathway inhibition impaired both components to a similar extent (two-way ANOVA treatment-by-memory type interaction F(2,66) = 9.320, ***P < 0.0005; main effect of treatment F(2,66) = 6.715, **P < 0.005; main effect of memory type F(1,66) = 9.620, **P < 0.005). FL/TD, familiar location/temporally distant; FL/TR, familiar location/temporally recent; NL/TD, novel location/temporally distant; NL/TR, novel location/temporally recent. Data are presented as mean ± SEM

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