Fig. 9 | Nature Communications

Fig. 9

From: Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment

Fig. 9

Model for the role of HDAC5 in regulating CXCR4 expression in human HSC/HPCs. HDAC5 inhibition by LMK235 results in enhanced acetylation of histone 3 on lysine 9 and histone 4 on lysine 16, as well as p65 acetylation. Acetylation of histone facilitates chromatin remodeling, whereas acetylation of p65 enhances its transcriptional activity. Acetylated p65 binds to CXCR4 promoter region and induces higher expression of CXCR4 and thus enhances HSC/HPC homing and engraftment

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