Fig. 6 | Nature Communications

Fig. 6

From: Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

Fig. 6The alternative text for this image may have been generated using AI.

Drug sensitivity profiling of 24 compounds against nine EAC organoids. Organoid cultures are clustered based on their drug sensitivity as measured by 1-AUC values across the drug panel. The drug names are provided at the bottom of the panel and the mutational signature subtype also indicated. Asterisks (*) identify drugs that elicited an IC50 below 1 µM while the histogram indicates the number of drugs for each organoid culture eliciting an IC50 below 1 or 0.1 μM

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