Fig. 1 | Nature Communications

Fig. 1

From: Impaired recruitment of dopamine neurons during working memory in mice with striatal D2 receptor overexpression

Fig. 1The alternative text for this image may have been generated using AI.

D2R-OE mice are impaired on a spatial working memory task. a Schematic of working memory task. During the “sample” phase animals were directed to enter one of the goal arms of the maze. After a brief delay period, in the “choice” phase they had to enter the opposite arm to obtain a reward (R). b % correct choices during each day of training in D2R-OE and control mice. c Days required to reach criterion performance (≥70% correct choices over three consecutive days) in the two groups. D2R-OE mice required more days of training (****p < .0001, n = 19 control mice and n = 17 D2R-OE mice, rank-sum test). d % correct choices during testing sessions (after reaching criterion) from which electrophysiological data was analyzed did not differ between genotypes (p = 0.1364, rank-sum test). Error bars represent mean ± s.e.m over animals

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