Fig. 8
From: Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice
Suppression of inflammation unmasks intrinsic effects of B. wadworthia on glucose homeostasis. Cytokine production in a spleen and b MLN of HFD fed mice receiving ciclosporine (Ci) and/or B. wadsworthia (Bw+) (*p < 0.05, n = 8–10/group). c B. wadsworthia load in the caecum (*p < 0.05, n = 8–10/group). d Weight gain after 9 weeks of HFD (****p < 0.0001 HFD vs. HFD-Ci; +++p < 0.001, ++++p < 0.0001 HFDBw+ vs. HFD-CiBw+, n = 8–10/group). e Blood glucose, f insulin, g homeostatic model assessment-insulin resistance (HOMA-IR) after 5–6 h of fasting. h Blood glucose level before and after oral glucose tolerance challenge (OGTT; 2 g/kg mouse; ***p < 0.001, *p < 0.05 HFD-Ci vs. HFD-CiBw+; n = 8–10/group). i Area under the curve (AUC) of OGTT. j Lipid area, calculated as % area of interest (AOI), in liver cross-sections stained with H&E. k Representative pictures of liver stained with H&E. Scale bar = 100 µm. Statistical comparison was performed by first testing normality using Kolmogorov–Smirnov test and then ANOVA or Kruskal–Wallis test with Bonferroni or Dunn’s post hoc test. Error bars represents SEM
