Table 3 Summary of results pertaining to schizophrenia genomic findings

Brain open chromatin regions are significantly enriched for schizophrenia SNP heritability

Fig. 2, Supplementary Fig. 4, Supplementary Fig. 5

This finding replicated in an independent sample

Schizophrenia SNP-heritability enrichment in open chromatin is second to that in regions conserved across 29 Eutherian mammals

Fig. 2a

Regions that are both conserved and in open chromatin are particularly enriched

Fig. 2f

Regions that are both conserved and in open chromatin are enriched for transcription factor binding sites with neuronal functions

Supplementary Data 2

Many cross-tissue biological features do not show schizophrenia SNP-heritability enrichment (e.g., promoters, other epigenetic marks)

Fig. 2a

Schizophrenia SNP-heritability enrichment in the DLPFC is relatively specific and not a feature of GWA generally

Fig. 2d

Adult DLPFC displays similar heritability enrichment relative to fetal PFC

Fig. 2b

Studying adult brain was crucial: higher enrichment compared to 138 tissues/cell types

Fig. 2b, Supplementary Fig. 5

Few differences in chromatin accessibility between schizophrenia cases and controls.

Fig. 3e, f

Six thousand two hundred cQTLs were identified. Eight of them colocalize with schizophrenia GWA signal. One also colocalizes with eQTLs of two genes (AS3MT and WBP1L)

Table 3, Supplementary Fig. 7