Fig. 1

Synthesis of peptidomimetics containing aryl sulfonamide motif. a Bioactive benzylsulfonamide and benzosultam-containing peptidomimetics. b Peptide-guided functionalization and macrocyclization of sulfonamide-containing peptidomimetics by Pd(II)-catalyzed late-stage C–H activation. HAT human airway trypsin-like protease