Fig. 6 | Nature Communications

Fig. 6

From: NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer

Fig. 6

NOVA1 binds to a deep intronic sequence in hTERT DR8 and acts as a splicing enhancer to promote the inclusion of exons 7/8 and greater levels of full-length hTERT mRNAs. a Linear model depicting NOVA1 binding to TERT DR8 promoting the inclusion of exons 7/8. b Alternative model of NOVA1 promoting full-length TERT considering RNA:RNA pairing/RNA secondary structure of TERT pre-mRNAs

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