Fig. 1 | Nature Communications

Fig. 1

From: PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

Fig. 1

Prophylactic, but not therapeutic treatment with the inhaled PI3Kδ inhibitor nemiralisib mitigates disease severity following S. pneumoniae infection in wild-type mice. Wild-type mice were treated twice daily with the inhaled PI3Kδ inhibitor nemiralisib for the duration of the study: when treatment was started 24 h prior to infection with S. pneumoniae serotype 4, TIGR 4, survival rates were improved. When started 8 or 24 h post-infection, the treatment had no effect on survival outcome. (−24 h: data from five independent experiments combined n = 60; +8 h/+24 h: data from three independent experiments combined n = 36; data-points represent individual animals)

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