Fig. 6 | Nature Communications

Fig. 6

From: PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner

Fig. 6

B cells could drive increased pathology in response to S. pneumoniae infection, independent of bacterial clearance. Ighmtm1 (µMT) mice show delayed disease progression and improved overall survival up to 30 days post S. pneumoniae infection, however 41% (7/17) surviving Ighmtm1 mice failed to clear bacteria from the lung tissue at 30 days post-infection compared to 100% clearance in surviving wild-type mice. (Data from 1 study, n = 24, mean CFU count shown, data-points represent individual animals)

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