Fig. 6

Superimposed structures of KRAS₁₆₉^Q61H-Abd-7 and RAS-effectors (RAF, Pi3K and RALGDS). The potential interactions that could prevent Abd-7 and a RAS effector binding simultaneously to the same KRAS molecule have been modelled by overlaying the structure of the KRAS₁₆₉^Q61H-Abd-7 complex onto published structures. In each case, simultaneous binding of KRAS to Abd-7 and the effector is sterically forbidden. a, b Overlay with HRAS-CRAF RBD (PDB 4G3X). Abd-7 would overlap with residues 62-67 of CRAF. c, d Overlay with HRAS-RALGDS RBD (PDB 1LFD). Abd-7 would overlap with residues 29-31 of RALGDS. e, f Overlay with HRAS-PI3Kγ RBD (PDB 1HE8). Abd-7 would overlap with residues 227-229 for PI3K