Fig. 10
From: p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
Central ghrelin fails to stimulate food intake and body weight in AgRPp53 KO mice. Body weight change (a); cumulative food intake (b); ARC mRNA expression of NPY and AgRP (c); representative WAT histology pictures (hematoxylin-eosin) (d); mRNA expression of FAS, ACC, and LPL in the WAT of control (e) and AgRPp53 KO mice (f) and serum acyl-ghrelin levels in control and AgRPp53 KO mice treated i.c.v. with saline or ghrelin. Values are mean ± SEM of 6–9 animals per group. *P < 0.05; **P < 0.01
