Fig. 4 | Nature Communications

Fig. 4

From: BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma

Fig. 4The alt text for this image may have been generated using AI.

BCL11A regulates both SETD8 and SKIL gene expression. SETD8 (a), SKIL (b), TBX2 (c), BCL11A (d), SOX2 (e) gene expression in NSCLC cell lines. f Sorting strategy for RNA extraction from WT or BCL11AOVX mice treated with tamoxifen. SETD8 (g), SKIL (h), TBX2 (i), BCL11A (j), SOX2 (k) gene expression in basal stem cells. SETD8 (l), SKIL (m), TBX2 (n), BCL11A (o), SOX2 (p) gene expression in epithelial Epcam+ve cells. The whiskers in all box plots represent minimum and maximum points. The box extends from 25th to 75th percentile and the line represents the median. Data presented as mean ± s.d. (LUSC n = 5 and LUAD n = 6; WT n = 3 and BCL11AOVX n = 3). Student’s t-test performed, *p < 0.05, **p < 0.005, and ***p < 0.001

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