Fig. 6
Compartmental representation of P. vivax transmission model in humans. Infected individuals can be in one of three compartments depending on whether blood-stage parasitaemia is detectable by PCR (IPCR), light microscopy (ILM) or has high density with accompanying fever (ID). A proportion of individuals that progress to a symptomatic episode of P. vivax will undergo treatment with a blood-stage drug (T) leading to clearance of blood-stage parasitaemia and a period of prophylactic protection (P) before returning to the susceptible state (S). The superscript k denotes the number of batches of relapse causing hypnozoites in the liver. Red arrows denote new blood-stage infections arising from either new mosquito bites or relapses. Each square denotes a compartment and the circles denote the dependence of transition rates between compartments on levels of anti-parasite immunity (Ap) and levels of clinical immunity (Ac)
