Fig. 2
From: Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity
Asian regional association plots of variants in the MHC region and lung cancer overall and major histologies (a–c); plots of stepwise conditional analyses for lung adenocarcinoma (b. 1–b. 4). Each panel on the left shows the association plot for each analysis a lung cancer overall, b adenocarcinoma, c squamous cell carcinoma. The association for each locus used for conditioning is shown in green in each panel on the right (b. 1) unconditioned, (b. 2) conditioned on HLA-DQB1*0401, (b. 3) conditioned on HLA-DQB1*0401 and HLA-DRB1*0701, (b. 4) conditioned on HLA-DQB1*0401, HLA-DRB1*0701 and rs2256919 (SNP within HLA-A). Detailed association results in Table 3 and Supplementary Figure 1. Circles represent –log10 (P values) for each binary marker using the imputed allelic dosage (between 0 and 2). The dashed black horizontal lines represent the study-wide significant threshold of P = 6 × 10−6. The physical positions of HLA genes on chromosome 6 are shown at the bottom. The color of the circles indicates the type of marker; light blue—SNPs, green—classical HLA alleles, and red—amino acid polymorphisms of the HLA genes
