Table 3 Top associations of the HLA alleles with adenocarcinoma of Asian ancestry

From: Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

Locus

Variant

Frequency

Unconditional analysisa

Model including HLA-DQB1 *0401 + HLA-DRB1*0701 + rs2256919

  

Controlsb

Casesb

OR (95% CI)

P value

OR (95%CI)

P value

HLA-DQB1

04:01

0.06

0.09

1.67 (1.35-2.05)

1.59 × 10−06

1.73 (1.41-2.14)

2.85 × 10−07

HLA-DRB1

07:01

0.05

0.09

1.62 (1.31-2.01)

5.48 × 10−06

1.63 (1.32-2.03)

5.34 × 10−06

HLA_A (intronic)

rs2256919

0.44

0.38

0.75 (0.67-0.83)

1.75 × 10−07

0.76 (0.68-0.85)

8.92 × 10−07

  1. HLA human leucocyte antigen, OR odds ratio, 95% CI confidence interval
  2. a Obtained from multivariate unconditional logistic regression assuming an additive genetic model with sex and principal components as covariates
  3. b Number of samples included in the analysis: 1192 cases and 1656 controls
  4. The study-wide significant threshold was P = 6 × 10−6 (Bonferroni correction)
Back to article page