Fig. 2
From: HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction
Structural and accessory proteins of HIV-1 do not encode immune activation determinants. a–c Gag or GFP (viral) expression (a), CD169 expression (b), and IP-10 production (c) in MDMs 6 days post infection with replication competent HIV-1 (Vpu + / − and Env + ) or VSV-G-pseudotyped single-round viruses (Nef + / - , Env − , Vpr + / − , and Vif + / − ) at MOI of 1. d Schematic of HIV-1 Gag mutants. e–m Gag or GFP (viral) expression (e, h, k), CD169 expression (f, i, l), and IP-10 production (g, j, m) in MDMs 6 days post infection with HIV-1 (MOI of 2). m: mock. The means ± SEM are shown and each symbol represents an independent experiment. Two-tailed p-values: one-way ANOVA followed by the Tukey-Kramer post-test (b, c, f, g, i, j, l and m) and/or the Dunnett’s post-test (f, g, i, and j), or paired t-test (k). *p < 0.05, **p < 0.01, ***p < 0.001, ns: not significant
