Fig. 2 | Nature Communications

Fig. 2

From: Ribitol restores functionally glycosylated α-dystroglycan and improves muscle function in dystrophic FKRP-mutant mice

Fig. 2

Detection and quantification of ribitol, ribitol-5P, and CDP-ribitol by LC/MS-MS. a LC/MS-MS detection of ribitol, ribitol-5P, and CDP-ribitol from heart and quadriceps of 4-week-old P448L mice treated with drinking water only (untreated) or water supplemented with 5% ribitol for 1 month. b Quantification of ribitol, ribitol-5P, and CDP-ribitol levels by LC/MS-MS from heart (H) and quadriceps (Q) of untreated and 5% ribitol-treated P448L mice, and untreated C57 control mice (n = 4 for all cohorts). Box represents 25th and 75th percentiles. Line represents median and “+” represents mean. Whiskers extend from min to max value. Unpaired t test, *p ≤ 0.05

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