Fig. 5
Effect of ribitol treatment on muscle fibrosis in P448L mice. Seven-week-old P448L mice were given drinking water only or drinking water supplemented with 5% ribitol for either 3 months (3M) or 6 months (6M). a Masson’s Trichrome staining of heart, tibialis anterior (TA), and diaphragm muscles from untreated (untreated 3M and untreated 6M) or 5% ribitol-treated (5% ribitol 3M and 5% ribitol 6M) P448L and C57 mice. Blue staining represents area of fibrotic tissue. Scale bar, 100 μm. b Percentage of fibrotic areas quantified from Masson’s Trichrome staining of 3 months (3M) and 6 months (6M) untreated and 5% ribitol-treated heart, TA, quadriceps (QUAD), and diaphragm (DIAPH) muscles (n = 6 for 3M, n = 4 for all other cohorts). Error bars represent mean ± SEM. Unpaired t test, *p ≤ 0.05
