Table 4 Significant and retained interactions from post hoc gene set by gene set interaction analysis for pulse pressure

From: Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure

Gene-set interaction pair

Size

Overlap

Marginal p-value

Full model p-values

Shared

 

Main

Interaction

Cardiovascular system development (BP)a

764

100

1.79e-9

2.74e-5

1.44e-5

(1)

 × Chemical homoeostasis (BP)

844

0.000672

0.0836

Cardiovascular system development (BP)a 

764

147

1.79e-9

0.000210

2.01e-5

(1)

 ×  Homoeostatic process (BP)

1277

0.000981

0.100

Cell adhesion molecule binding (MF) 

180

21

1.28e-6

0.000574

0.000751

 

 ×  Glycosaminoglycan binding (MF)

201

0.0904

0.602

 

Cell proliferation (BP) 

645

204

1.60e-8

0.00311

0.000204

 

 ×  Regulation of intracellular signal transduction (BP)

1581

0.0197

0.340

 

Cell proliferation (BP) 

645

74

1.60e-8

5.51e-5

7.62e-6

 

 × Regulation of intracellular signal transduction (BP)

596

0.454

0.958

 

Regulation of transcription from RNA polymerase II promotor (BP)  

1682

203

9.97e-7

0.00127

1.73e-5

 

 ×  Homoeostatic process (BP)

1277

0.000981

0.125

 
  1. Marginal gene-set p-values are from step 2 of the analysis workflow, after correcting for general confounders. Interactions that likely reflect a single shared association are marked by the same number in the ‘Shared’ column
  2. BP biological process, MF molecular function
  3. a The same interaction exists for circulatory system development, which is identical to cardiovascular system development and therefore omitted from this table
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