Fig. 6

Mutation-responsive effects underlie differences in phenotypic variance between knockout and wild-type backgrounds across environments. Each point’s position on the x axis represents the difference in phenotypic variance between a knockout background of the cross (V_P.Mut) and the wild-type background of the cross (V_P.WT) in a single environment. The y axis shows the difference in the number of mutation-responsive effects with enhanced and reduced phenotypic effects. In this paper, we classified mutation-responsive effects as enhanced or reduced based on whether they explained more or less phenotypic variance in mutants relative to wild-type segregants, respectively. Spearman’s ρ and its associated p value are provided on the plot. Colors denote different knockout backgrounds