Fig. 4
From: Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
Comparison of Cryo-EM reconstructions of membrane-bound and corresponding soluble trimers. a Cryo-EM reconstruction of BG505 ΔCT T332 in complex with PGT151 Fab at 4.5 Å resolution. b Cryo-EM reconstruction of B41 ΔCT in complex with PGT151 Fab at 6.7 Å resolution. c Structural differences between BG505 ΔCT T332 and soluble BG505 SOSIP trimer (PDB: 5ACO). d Close-up of the V1/V2 region highlighted in c. e Mapping of site-specific glycan processing of JR-FL ΔCT, BG505 ΔCT T332, and B41 ΔCT onto the surface of the corresponding cryo-EM density maps with two PGT151 Fabs highlighted per trimer
