Fig. 2
From: Contribution of allelic imbalance to colorectal cancer
Somatic copy number with respect to single-base substitutions. a Increasing number of single base variant calls per megabase of reference sequence as a function of copy number (LRR, Log R Ratio). b Nearly uniform mean proportion of mutated reads as a function of LRR when at least a normal number of DNA copies are present. c Nearly uniform number of mutated reads observed per SNV as a function of LRR. Mean number of reference allele reads for comparison (red, lowess fit). Each (green) point stands for an AI segment (a) or a point mutation (b, c) on strictly callable38 genome segment with called AI in MSS tumors. Blue lowess fit curves are provided as a visual guide. LRR axes cover more than 99.9% of AI regions
