Table 1 Demographics of patients with known fungal loads determined by mycobiome analysis
From: Lung colonization by Aspergillus fumigatus is controlled by ZNF77
Total | rs35699176−/− | rs35699176+/− | P-value | |
|---|---|---|---|---|
ABPA (n = 7) | ||||
BMI | 25.71 ± 2.64 | 25.62 ± 2.73 | 25.78 ± 2.57 | ns |
Smokers or ex-smokers | 14.28% | 0% | 25% | ns |
Forced expiratory volume (FEV, l) | 1.64 ± 0.6 | 1.31 ± 0.1 | 1.80 ± 0.55 | ns |
Forced vital capacity (FVC, l) | 3.11 ± 0.85 | 2.91 ± 0.62 | 3.21 ± 0.95 | ns |
FEV/FEC (%) | 54.78 ± 14.08 | 50.31 ± 7.51 | 58.14 ± 16.65 | ns |
Total IgE > 1000 IU | 28% | 33% | 25% | ns |
log10 Aspergillus genome equivalents | 2.47 ± 1.04 | 1.90 ± 0.62 | 2.90 ± 0.94 | 0.0001 |
SAFS (n = 6) | ||||
BMI | 25.7 ± 4 | 25.7 ± 4 | nf | nf |
Smokers or ex-smokers | 16.66% | 16.66% | nf | nf |
Forced expiratory volume (FEV, l) | 2.14 ± 0.81 | 2.14 ± 0.81 | nf | nf |
Forced vital capacity (FVC, l) | 3.71 ± 1.6 | 3.71 ± 1.6 | nf | nf |
FEV/FEC (%) | 56.13 ± 9.98 | 56.13 ± 9.98 | nf | nf |
Total IgE > 1000 IU | 0% | 0% | nf | nf |
log10 Aspergillus genome equivalents | 1.55 ± 0.55 | 1.55 ± 0.55 | nf | nf |
Asthmatics (n = 4) | ||||
BMI | 28 ± 2 | 28 ± 2 | nf | nf |
Smokers or ex-smokers | 25% | 25% | nf | nf |
Forced expiratory volume (FEV, l) | 2.20 ± 1.02 | 2.20 ± 1.02 | nf | nf |
Forced vital capacity (FVC, l) | 3.52 ± 1.02 | 3.52 ± 1.02 | nf | nf |
FEV/FEC (%) | 59.65 ± 9.75 | 59.65 ± 9.75 | nf | nf |
Total IgE > 1000 IU | 0% | 0% | nf | nf |
log10 Aspergillus genome equivalents | 1.27 ± 0.31 | 1.27 ± 0.31 | nf | nf |
Healthy controls (n = 4) | ||||
BMI | 32 ± 9 | 32 ± 9 | nf | nf |
Smokers or ex-smokers | 0% | 0% | nf | nf |
Forced expiratory volume (FEV, l) | n/a | n/a | nf | nf |
Forced vital capacity (FVC, l) | n/a | n/a | nf | nf |
FEV/FEC (%) | n/a | n/a | nf | nf |
Total IgE > 1000 IU | 0% | 0% | nf | nf |
log10 Aspergillus genome equivalents | 1.05 ± 0.28 | 1.05 ± 0.28 | nf | nf |
