Fig. 10 | Nature Communications

Fig. 10

From: Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape change for epithelial morphogenesis

Fig. 10

Cytoplasmic localization of GRHL3 upon epidermal differentiation triggers cell shape changes. GRHL3 exerts two different functions related to epidermal fate specification and epithelial morphogenesis during the course of epidermal development. The former function is mediated by N-GRHL3 as a downstream transcriptional factor of β-catenin. The latter function is mediated by C-GRHL3 involving the non-canonical Wnt pathway, e.g. planar cell polarity molecules. The non-canonical Wnt pathway facilitates actomyosin networks and, consequently, alters physical properties such as the mechanical stiffness of cells necessary for epithelial morphogenesis. The cytoplasmic localization of GRHL3 during epidermal differentiation appears to be controlled by CP2, C-terminus, and N-terminus domains of GRHL3. Thus, this cytoplasmic localization of GRHL3 triggers cell shape changes in epithelial morphogenesis from epidermal differentiation during embryonic development. SE Surface ectoderm, NE Neural ectoderm

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