Fig. 3
From: A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
WJ460 abrogates breast cancer lung extravasation and colonization. a MDA-MB-231-Luciferase cells were inoculated intravenously into female nude mice. DMSO or WJ460 was injected intraperitoneally on day 0. Lung metastasis was monitored by bioluminescence using an in vivo imaging system. b Quantification of bioluminescence. n = 6 mice per group. c H&E staining of lungs from the indicated groups upon harvest (day 28). Scale bars, 0.4 cm. d Mice were intravenously injected with MDA-MB-231-Luciferase-GFP cells and sacrificed at the indicated times. Lungs were stained for CD31 (red) and GFP (green). Confocal images were acquired. Scale bars, 10 μm. n = 6 mice per group. e Overall survival rate of mice in different treatment groups. n = 8 mice per group. **p < 0.01, ***p < 0.001
