Fig. 3 | Nature Communications

Fig. 3

From: Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies

Fig. 3The alternative text for this image may have been generated using AI.

Schematic and mathematical model of Ebola virus infection. As the virus early disseminate in blood and lymph circulation, the model assumes only one target cell compartment. After infection by free virus (V), target cells (T) enter an eclipse phase (I1) before becoming productively infected (I2), which activate macrophage and production of cytokines. Cytokine release, in particular IFNα, leads to an increase of cells that are refractory to infection (R), and triggers apoptosis of non-specific CD8 T cells (E1), which creates room for proliferation of EBOV-specific CD8 T cells (E2) that eliminate productively infected cells I2 Polymerase inhibitors as favipiravir inhibit viral production with efficacy ε

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