Fig. 5 | Nature Communications

Fig. 5

From: Ebola viral dynamics in nonhuman primates provides insights into virus immuno-pathogenesis and antiviral strategies

Fig. 5The alternative text for this image may have been generated using AI.

Individual observation (dots) and median model predictions (line) in animals left untreated (black) or treated with 180 mg kg−1 BID favipiravir (red). Top left: Ebola virus viral load; top middle CD8 T cells expressing perforin; top right: model prediction of productive infected cell elimination rate, increasing concomitantly to adaptive response; middle left: IFNα concentrations; middle: IL6 concentration; middle right: TNFα concentration; bottom left: predicted ratio of protected cells on the concentration of IFNα (R/F); bottom middle: model prediction of the ratio of infected on protected cells (R/I2); bottom right: Kaplan Meier curves and survival rate prediction. Shaded areas represent the predictions within the 10th and 90th percentiles of 1000 simulations

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